A drugnutrient interaction is a reaction between a medicine and one or more nutrients. If the client is taking a drug or medication that isnt on this list, check the foodmedications interactions book for possible side effects. View, save, email or print a full interaction report. Clopidogrel drug information kaiser permanente washington. Tetracycline barberry berberine, a chemical extracted from goldenseal hydrastis canadensis,barberry berberis vulgaris, and oregon grape berberis aquifolium, has been shown to have antibacterial activity. Examples of affected drugs include dasabuvir, repaglinide, among others. Meds 325 asprin, lisinopril 10mg daily, lipitor 40 mg, metorolol 25mg daily, plavix 75 mg daily zetia 5mg daily. Clopidogrel can slow down the removal of other drugs from your body, which may affect how they work. The information contained herein should not be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Clopidogrel, sold under the trade name plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk.
Approximately 50% of clopidogrel is excreted in the urine and 45% in the feces. People taking prescription drugs may be more likely to have reduced levels of certain nutrients. Drug nutrient interactions table of common drugs and medications. The impact of the nutrientdrug interaction may vary according to the medicine taken, the dose of the medicine given, and the form taken e. Plavix may interact with a number of different drugs. Repeated doses of 75 mg plavix per day inhibit adpinduced platelet.
Clot formation can decrease blood flow to the brain and heart. Plavix clopidrogrel nutrient interaction depletion. Handbook of drugnutrient interactions, second edition is an essential new work that provides a scientific look behind many drugnutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is.
The consequences of dietnutrientdrug interactions include decreased tolerance of nutritional support, loss of feeding access, decreased drug efficacy, nutrient malabsorption or. Food medication interactions 19th edition zaneta m pronsky ms rd ldn fada, dean elbe bsc pharm bcpp pharm d, laura finn bcgp fascp, william roberts md phd, keith ayoob edd rd fada, sol epstein md frcp facp on. Other plavix precautions and warnings involve the risk for major bleeding associated with the drug. If you are taking drugs, you may need to avoid certain foods.
Concomitant use of certain inhibitors of this enzyme results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition. Pharmacokinetic drug interactions with clopidogrel. Handbook of drugnutrient interactions, 2nd edition nutrition and. In this guide, a fooddrug interaction is a change in how a medicine works caused by food, caffeine, or alcohol. Plavix should be avoided in patients who have some genetic disorders e. Elderly persons are at a significant risk for nutrientdrug interactions. Drugnutrient interaction is defined as an alteration of the kinetics or dynamics of a drug or nutrient, or the impairment of the nutritional status caused by drug administration. When discussing yours or your infants needs with your practitioner please ensure to mention all other treatments already being used. Simply enter a drug andor a nutrient andor an herb into the search field to learn about documented and theoretical interactions. For people taking plavix, drug interactions may be a concern.
Handbook of drugnutrient interactions, second edition is a comprehensive uptodate text for the total management of patients on drug andor nutrition therapy but also an insight into the recent developments in drugnutrition interactions which will act as a reliable reference for. Nutrients are the vitamins and minerals that are in the food you eat. Handbook of drugnutrient interactions second edition edited by joseph i. Handbook of drugnutrient interactions springerlink. Should not be taken with proton pump inhibitors, use with caution with other anticoagulants warfarin, aspirin. Blood clots can form in blood as a result of certain heart. Handbook of drugnutrient interactions nutrition and health. It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent dual antiplatelet therapy. The drugs may make the anticlotting drug plavix dangerously less effective, the fda says.
We would like to show you a description here but the site wont allow us. Drug nutrient interactions south denver cardiology. Clopidogrel is metabolized to its active metabolite in part by cyp2c19. Because the medication does not work as well in these people, they may be at a higher risk of having a heart attack or stroke. This database allows you to find potential drug and nutrient interactions that could affect your recommendations. It belongs to a class of drugs called p2y12 inhibitors. Fda warns plavix patients of drug interactions webmd. Much of the information on this page came from ross peltons druginduced nutrient depletion handbook, because he posted it on the nutrition science news website, before they folded in 2002. Precautions and warnings concerning plavix include telling your doctor about any active bleeding you are experiencing such as a stomach ulcer and any bleeding or blood disorder you may have. Clopidogrel bisulfate plavix is an antiplatelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. Here, consumer reports lists food and drug interactions that you need to know about to stay safe. Drugnutrient interactions please ensure all medications, natural or mainstream are prescribedrecommendedapproved by a registered practitioner and administered using prescribed instructions.
Anticoagulants decrease the potential for clotting via the prothrombin. See what the interactions are and for which people. For educational use by healthcare professionals only. The clopidogrel manufacturer states that a dose adjustment of the cyp2c8 substrate may be necessary. Nutrient drug interactions effects of nutrition on pharmacokinetics and pharmacodynamics of drugs rebecca white lead pharmacist. This population often takes the highest amount of medications, and. Plavix, or clopidogrel bisulfate, keeps platelets from clumping to form blood clots. What foods can or cannot be eaten when using plavix. Pdf pharmacokinetic drug interactions with clopidogrel. Drug interactions are reported among people who take plavix and prevacid together. Handbook of drugnutrient interactions nutrition and. Vitamins and minerals nourish your body and help to keep you healthy and reduce your risk for chronic diseases. If so, you may be at increased risk for drug interactions, which occur when a drug.
Nutrientdrug interactions nutritional disorders msd. The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking drugdrug interaction, food, beverages, dietary supplements the person is consuming drugnutrientfood interaction or another disease the person has drugdisease interaction. This tool may not cover all possible drug interactions. We look into the drug interactions by gender and age. Plavix belongs to a class of drugs known as blood thinners. Pdf coprescribing of clopidogrel and other drugs is common.
Drug interactions are reported among people who take plavix and lasix together. Antiplatelet drugs work best when used with hearthealthy lifestyle changes such as regular exercise and a balanced diet, according to the american heart association. Then i began cardiac rehab for 6 weeks and was working out at 60 minutes a day at achieving a met level of 7. Kinetics refers to the quantitative description of a drug or its availability, which includes absorption, distribution, metabolism, and. Severe energy and protein deficiencies reduce enzyme tissue concentrations and may impair the response to drugs by reducing absorption or protein binding and causing liver dysfunction. Plavix clopidogrel bisulfate generic, side effects. Drugnutrient interactions in the intensive care unit. Uses, side effects, interactions, pictures, warnings. Handbook of drug nutrient interactions, second edition is a comprehensive uptodate text for the total management of patients on drug andor nutrition therapy but also an insight into the recent developments in drug nutrition interactions which will act as a reliable reference for clinicians and students for many years to come. This study is created by ehealthme based on reports of 2,998 people who take plavix and prevacid from the food and drug administration fda, and is updated regularly. The novel and potentially relevant ddis between morphine and oral. Read the medication guide provided by your pharmacist before you. Plavix is the brand name form of the generic drug clopidogrel bisulfate, an antiplatelet medication thats used to prevent blood clots. At steady state, the average inhibition level observed with a dose of 75 mg plavix per day was between 40% and 60%.
Eating grapefruit can inhibit cytochrome p450 34a, slowing metabolism of some drugs eg, amiodarone. Plasma concentrations of the inactive metabolite and the degree of platelet inhibition are reduced in patients with severe renal impairment creatinine clearance of 515 mlmin. Definition of termsdefinition of terms drugnutrient interaction. Onset of effects is about two hours and lasts for five days. In the five years since publication of the first edition of the handbook of drugnutrient interactions new perspectives have emerged and. Changes in the gastrointestinal tract can impair absorption and affect the response to a drug. Plavix clopidogrel bisulfate dose, indications, adverse. The use of plavix in cure was associated with a decrease in the use of thrombolytic therapy 71 patients 1.
The information provided here is for informational purposes only. Plavix and lasix drug interactions a study of fda data. Nutritional deficiencies can affect drug absorption and metabolism. At the time of this writing, no evidence of nutrient or herb interactions involving clopidogrel was found in the medical literature. Coadministration of plavix with omeprazole, a proton. For instance, taking plavix and warfarin together may increase the risk of bleeding, as can taking nonsteroidal antiinflammatory drugs nsaids with plavix. Drug nutrient interaction a pysicochemical, physiological or pathophysiological process that alters disposition, function or toxicity of a food component or drug.
Foods can enhance, delay, or decrease drug absorption. Plavix can interact with a number of different medications. The dabrafenib auc value increased by 47% when dabrafenib was administered with another strong cyp2c8 inhibitor in a drug interaction study. Drugnutrient interaction checker integrative therapeutics. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an. If the client is taking a drug or medication that isnt on this list, check the food medications interactions book for possible side effects. Warfarin and vitamin k warfarin coumadin is a bloodthinning medication that helps treat and prevent blood clots.
When a medicine interacts with a nutrient, it can keep the medicine from. They block an enzyme in the body that turns the drug into its active form. Handbook of fooddrug interactions nutrition assessment. Its possible to integrate foods of all types into a healthy diet as long as theyre eaten in. This study is created by ehealthme based on reports of 12,576 people who take plavix and lasix from food and drug administration fda, and is updated regularly.
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